(2S)-2-aMino-3-MethylbutyraMide hydrochloride
L-valinamide hydrochloride
CAS: 3014-80-0
Molecular Formula: C5H13ClN2O
(2S)-2-aMino-3-MethylbutyraMide hydrochloride - Names and Identifiers
| Name | L-valinamide hydrochloride |
| Synonyms | L-Val-NH2 H-Val-NH HCl H-Val-NH2.HCl H-VAL-NH2 HCL L-Val-NH2·HCl VALINE-NH2 HC H-Val-NH2·HCl H-Val-NH2*HCl L-valine amide hcl L-valinamide hydrochloride L-Valinemide Hydrochloride (S)-2-aMino-3-MethylbutanaMide hydrochloride (2S)-2-aMino-3-MethylbutyraMide hydrochloride |
| CAS | 3014-80-0 |
| EINECS | 1533716-785-6 |
| InChI | InChI=1/C5H12N2O.ClH/c1-3(2)4(6)5(7)8;/h3-4H,6H2,1-2H3,(H2,7,8);1H |
(2S)-2-aMino-3-MethylbutyraMide hydrochloride - Physico-chemical Properties
| Molecular Formula | C5H13ClN2O |
| Molar Mass | 152.62 |
| Melting Point | 266-270°C(lit.) |
| Boling Point | 273.6°C at 760 mmHg |
| Flash Point | 119.3°C |
| Solubility | Soluble in methanol (50 mg/ ml-clear, colorless solution). |
| Vapor Presure | 0.00439mmHg at 25°C |
| Appearance | Crystallization |
| Color | White to Almost white |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 27 ° (C=1, H2O) |
| MDL | MFCD00039085 |
(2S)-2-aMino-3-MethylbutyraMide hydrochloride - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29241990 |
(2S)-2-aMino-3-MethylbutyraMide hydrochloride - Reference Information
| introduction | L-valinamide hydrochloride is solid at normal temperature and pressure. it is an amino acid derivative and is closely related to biological macromolecular peptides and proteins. In medicine, it can be used to prepare compound amino acid infusion, as well as therapeutic drugs and synthetic polypeptide drugs. |
| Use | L-valinamide hydrochloride can be used as a therapeutic drug and for the synthesis of polypeptide drugs. In organic synthesis and transformation, it needs to be first The form of hydrochloride is dissociated; the obtained amide structure can obtain the product of two amino groups under the action of a reducing agent. |
| preparation method | add DIPEA (3.6 mL, 20.7 mmol) and PyBrop (3.4g, 6.9 mmol) to the N-Boc amino acid (1.5g, 6.9 mmol) solution in CH2Cl2 (25 mL) at room temperature, then add methylamine (6.9 mL,13.8 mmol), 2.0 M in CH2Cl2 ), the resulting solution was stirred at room temperature for 18 hours (until TLC analysis considered the reaction complete). The resulting mixture was sequentially washed with saturated 10% citric acid (3 x 20 mL), saturated sodium bicarbonate (3 x 20 mL) and saline (3 x 20 mL). The organic layer is dried, filtered and concentrated under reduced pressure. The crude product was purified by rapid chromatography and eluted with CH 2 Cl 2 /MeOH (40:1) to obtain 1.0g (63% yield) solid. Figure The synthetic route of L-valinamide hydrochloride |
Last Update：2024-04-09 15:16:49
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